Adenium obesum is a popular houseplant and bonsai in temperate regions. It requires a sunny location and a minimum indoor temperature in winter of 10 °C (50 °F). It thrives on a xeric watering regime as required by cacti. A. obesum is typically propagated by seed or stem cuttings. The numerous hybrids are propagated mainly by grafting on to seedling rootstock. While plants grown from seed are more likely to have the swollen caudex at a young age, with time many cutting-grown plants cannot be distinguished from seedlings. Like many plants, Adenium obesum can also be propagated in vitro using plant tissue culture.